# Pharma.ai Webinar 2026 Q2 Summer Updates

Design and optimize small molecules with Generative AI and Physics-based methods.

Chemistry42 is a comprehensive small molecules drug discovery platform. It streamlines hit identification, hit-to-lead, and lead optimization programs.

## Generative Chemistry

Create novel small molecules with optimized properties using generative AI: de novo design, hit optimization, scaffold hopping and R-groups search.

## Retrosynthesis

Predict synthetic routes for uploaded or generated molecular structures. Trained on the unique library of Expert-annotated Reaction templates.

## ADMET & Off-target

Comprehensive profiling and optimization of key absorption, distribution, metabolism, and toxicity parameters, as well as evaluation of selectivity profiles.

## MDFlow

End-to-end simulation workflows for biomolecules and complexes, from system build and sampling to reproducible reporting and metrics.

## Alchemistry

Accurately estimate the relative binding free energy to prioritize molecules with efficient physics-based methods.

## Model Training

Train a predictive model to navigate generation and annotate custom datasets.

## Golden Cubes

Golden Cubes is a proprietary engine that achieves high accuracy thanks to multi-dimensional Self-Organizing Maps. Predict off-target kinome selectivity.

## Contact Us

For inquiries: pharma.ai@insilicomedicine.com.