## Affected Pathways

Differentially expressed genes are calculated using the Pandomics's proprietary **iPANDA** method

### Insilico Medicine

Ozerov, I., Lezhnina, K., Izumchenko, E. _et al._ _In silico_ Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development. _Nat Commun_ 7, 13427 (2016). [https://doi.org/10.1038/ncomms13427](https://doi.org/10.1038/ncomms13427)

The chart represents the grouping of Reactome pathways by the high-level processes affected. Each bar represents the total number of process related pathways divided in three groups:

- Significantly **activated** pathways
- Significantly **inhibited** pathways
- Pathways which activity change is **not statistically significant** across all samples in the case group

Heatmap visualization located below the list of pathways allows you to assess pathway activation/inhibition across all the samples in the case group

### Training Video

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