250+ Peer-reviewed Publications

Generative Biology

• Comprehensive multi-omic dissection and AI-prioritized target identification in inverted papilloma–associated sinonasal squamous cell carcinoma
  npj | Precision Oncology
  July 10, 2026

• Target identification and assessment in the era of AI
  Nature Reviews Drug Discovery
  April 20, 2026

• Advancing target discovery through disease-specific integration of multi-modal target identification models and comprehensive benchmarking system
  Scientific Reports
  April 12, 2026

Opinion / Review

• GLP-1 receptor agonists should be rigorously tested as longevity therapeutics
  Nature Health
  April 03, 2026

Posters

• Abstract 4562: ISM6210, a potent and selective CDK4 inhibitor for the treatment of HR+/HER2- breast cancer
  Cancer Research
  April 03, 2026

• Abstract 425: ISM7713, a novel oral pan-KRAS (ON/OFF) inhibitor, shows robust anti-tumor activity in solid tumors with KRAS alterations
  Cancer Research
  April 03, 2026

• Abstract 7077: ISM1745, an MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted cancer
  Cancer Research
  April 03, 2026

• Abstract 4561: Cbl-b inhibition with ISM3830 restores innate and adaptive immunity and demonstrates antitumor activity against solid tumors in vitro and in vivo
  Cancer Research
  April 03, 2026

Generative Chemistry

• Cover Feature: An Internal Sulfur–Lone Pair Interaction Enabled the Discovery of Potent and Sub-Family Selective PKMYT1 Inhibitors (ChemMedChem 6/2026)
  ChemMedChem
  March 30, 2026

• An Internal Sulfur–Lone Pair Interaction Enabled the Discovery of Potent and Sub-Family Selective PKMYT1 Inhibitors
  ChemMedChem
  March 26, 2026

• Upskilling in Healthy Longevity Medicine and Its Association With Physicians’ Implementation Intent and Self-Reported Clinical Confidence: Cross-Sectional Observational Study
  March 19, 2026

• MMAI Gym for Science: Training Liquid Foundation Models for Drug Discovery
  March 03, 2026

• Molecular LEGION: incalculably large coverage of chemical space around the NLRP3 target
  Nature: Scientific Data
  March 03, 2026

Opinion / Review

• The Multi-Faceted Landscape of TEAD Inhibition: a 2017–2025 Patent and Literature Review
  Bioorganic Chemistry
  February 09, 2026

• When Single Answer Is Not Enough: Rethinking Single-Step Retrosynthesis Benchmarks for LLMs
  February 03, 2026

• From Prompt to Drug: Toward Pharmaceutical Superintelligence
  ACS Central Science
  February 02, 2026

• AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
  Aging and Disease
  February 01, 2026

• Conformational restriction of hinge carboxamide leading to potent lactam-based PKMYT1 inhibitors
  Bioorganic & Medicinal Chemistry
  January 31, 2026

Generative Biology

• LongevityBench: Are SotA LLMs ready for aging research?
  bioRxiv
  January 30, 2026

• PRECLINICAL TOXICOLOGY EVALUATION OF ISM5411: 13-WEEK ORAL ADMINISTRATION IN RATS AND BEAGLE DOGS
  Gastroenterology
  January 22, 2026

• ISM5411, A NOVEL GUT-RESTRICTED PHD1/2 INHIBITOR FOR INFLAMMATORY BOWEL DISEASE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, FIRST-IN-HUMAN PHASE I STUDY TO EVALUATE SAFETY, TOLERABILITY AND PK PR
  Gastroenterology
  January 22, 2026